Dubai PR Network, Online Press Release from Dubai and Middle East
 
Healthcare(Healthcare & Medicine)
Filter PR by
  
NYU Abu Dhabi Researchers Design Proteins That Can Be Utilized to Combat Alzheimer's Disease
 
NYU Abu Dhabi Researchers Design Proteins That Can Be Utilized to Combat Alzheimer's Disease
Protein-based therapeutics prevent protein aggregation associated with Alzheimer’s and other neurodegenerative diseases
 
Fast facts
● Alzheimer’s disease, an irreversible and progressive brain disorder, is the most common cause of dementia. 
● A hallmark of Alzheimer’s disease is the aggregation of the amyloid-β (Aβ) protein in a process that is toxic to the brain’s neurons. As neurons die, this slowly destroys memory and cognitive function. 
● NYUAD researchers have developed small proteins called cell-penetrating peptides (CPPs) that prevent the aggregation of the Aβ protein. 
● The paper Designed cell-penetrating peptide inhibitors of amyloid-beta aggregation and cytotoxicity has been published in Cell Reports Physical Science.
 
Abu Dhabi, UAE, February 7, 2020: A team of researchers, led by NYU Abu Dhabi Assistant Professor of Biology Mazin Magzoub, has developed small proteins called cell-penetrating peptides (CPPs) that prevent the aggregation of the amyloid-β (Aβ) protein associated with Alzheimer’s disease. 
 
There is a growing interest in the use of proteins to develop treatments because they are biocompatible, biodegradable, and can selectively bind to specific targets, which reduces the potential for toxicity. Other pharmaceutically-desirable properties of proteins include greater chemical diversity than other biological molecule classes, and ease and low cost of production. However, a significant obstacle to the successful application of most proteins as therapeutics is their poor delivery to target organs and cells. 
 
In a new study, the Magzoub lab in collaboration with Professor and NYU President Andrew Hamilton’s lab at NYU New York and Professor Astrid Gräslund’s lab at Stockholm University, report that they have engineered CPPs that effectively prevent the aggregation of Aβ. CPPs are a special class of proteins that have the ability to reach all organs, including the brain, and to efficiently enter cells within these organs. Thus, the designed CPPs combine the attractive properties of proteins with potent therapeutic effects and highly efficient delivery to target cells.
 
A broad range of neurodegenerative diseases, including Huntington’s, Parkinson’s, and Alzheimer’s, are caused by the misfolding of disease-specific proteins. Once misfolded, these proteins build up in a process that damages neurons. Previously, the team showed that a naturally-derived CPP was able to protect against abnormal and harmful forms of the protein associated with prion diseases, a class of neurodegenerative disorders that include mad cow disease in cattle and Creutzfeldt-Jakob disease (CJD) in humans. Here, Magzoub and his collaborators extended this approach and specifically applied it to Alzheimer’s disease-causing Aβ malformation. 
 
In the paper titled Designed cell-penetrating peptide inhibitors of amyloid-beta aggregation and cytotoxicity, the researchers present the process of designing the Aβ inhibitor CPPs. Using a range of techniques, they then extensively characterized the interactions of the designed CPPs with Aβ. Specifically, they used established aggregation and cell viability assays to determine the effects of the designed CPPs on the aggregation and associated neurotoxicity of Aβ. Simultaneously, they probed the cellular uptake and intracellular distribution of Aβ in the presence of the CPPs with confocal fluorescence microscopy. Finally, they used a combination of experiments and computer simulations to shed light on the mechanism of binding of the CPPs to Aβ. The results show that the designed CPPs stabilize the Aβ protein in a non-aggregated, non-abnormal state, and inhibit Aβ induced neurotoxicity.
 
The CPPs designed in this study effectively target Aβ outside and inside neurons, thereby protecting them against the damage caused by Aβ aggregation. “The designed CPPs represent a novel potential treatment strategy for Alzheimer’s disease,” said Magzoub. “These findings also reveal a general underlying principle for inhibition of pathogenic protein aggregation that will facilitate the design of even more potent CPP-based therapeutics for various neurodegenerative diseases.”


Posted by : Dubai PR Network Editorial Team
Viewed 8473 times
PR Category : Healthcare & Medicine
Posted on : Saturday, February 8, 2020  9:03:00 AM UAE local time (GMT+4)
Replication or redistribution in whole or in part is expressly prohibited without the prior written consent of DubaiPRNetwork.com.
Previous Story : Aster DM Healthcare Wins 6 Awards at AHPI Awards 2020
Next Story : Aster Hospitals Dubai achieves diamond level status from Acc...
Email this article Print this article

Share this article with your friends and followers
NewsVine
Back to Section Home

Related Stories



 
 
Most Viewed Press Release posted in the last 7 days
10 Million Plastic Packaging Saved: Grohe Launches Initiative to Reduce Plastic [3997-Views]
Meet the #Sephorasquad Middle East Members! [3997-Views]
Karl Lagerfeld Announces Collaboration With Designer Kenneth Ize [3563-Views]
Discover the Perfect Gift This Eid Al Adha From Rasasi Perfumes [3456-Views]
Amp Up Your Beauty Routine With New Products From Missha Cosmetics [2968-Views]
17-Year Old Smashed a Guinness World Records Title in His Bedroom [2813-Views]
Toric Tourbillon Slate'' [2669-Views]
Kia Launches ‘Live Stream Showroom' to Offer Customers an Innovative Digital Experience [2567-Views]
IMG Worlds is Back This Friday Park Entry Price at AED 20 Only [2534-Views]
Dubai Sports World Marks Official Opening at Dubai World Trade Centre [2513-Views]
Dubai Startup Hub and Dtec Announce Winners of Emirati Development Programme [2493-Views]
Celebrate Eid with Steve Madden [2480-Views]
Travellers Should ‘Wear to Care' in the New Normal says WTTC [2468-Views]
Champion Cleaners Launch New Home and Office Sanitization Service [2411-Views]
UAE Ranks in Top 10 on Kpmg's 2020 Global Autonomous Vehicles Readiness Index, for Third C... [2411-Views]
Cartier High Jewelry - Sur Naturel [2411-Views]
Al Habtoor Motors Launches Summer Surprises Stock clearance on Mitsubishi SUVs 2019 Model... [2247-Views]
Dubai Culture Wins Excellence Award From Arab Federation for Libraries and Information [2206-Views]
Dubai Customs' 2nd Consultative Council discusses challenges and opportunities of post Cov... [2206-Views]
FDA Authorizes Marketing of IQOS as a Modified Risk Tobacco Product [2066-Views]
Dubai Sports Council Honours Winners of Pocari Sweat 19K Run [2054-Views]
Gems Education Rolls Out IBM Digital – Nation Platform to All Its Schools Following Succes... [2042-Views]
It All Started with a Sponge- Gaetano Pesce's Revolutionary Feminist Chair “UP” On Display... [2025-Views]
Genesis Launches Special-Edition “stardust” G90 Model [2009-Views]
Skycap's Flagship Program of Us$150 M Global Fintech Investment on the Roadmap [1976-Views]
 
RSS Facebook Twitter LinkedDin
 
Top Sections
 
Top Stories